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Neurological manifestations and implications of COVID-19 pandemic.

Identifieur interne : 000A69 ( Main/Exploration ); précédent : 000A68; suivant : 000A70

Neurological manifestations and implications of COVID-19 pandemic.

Auteurs : Georgios Tsivgoulis [Grèce] ; Lina Palaiodimou [Grèce] ; Aristeidis H. Katsanos [Grèce] ; Valeria Caso [Italie] ; Martin Köhrmann [Allemagne] ; Carlos Molina [Espagne] ; Charlotte Cordonnier [France] ; Urs Fischer [Suisse] ; Peter Kelly [Irlande (pays)] ; Vijay K. Sharma [Singapour] ; Amanda C. Chan [Singapour] ; Ramin Zand [États-Unis] ; Amrou Sarraj [États-Unis] ; Peter D. Schellinger [Allemagne] ; Konstantinos I. Voumvourakis [Grèce] ; Nikolaos Grigoriadis [Grèce] ; Andrei V. Alexandrov [États-Unis] ; Sotirios Tsiodras [Grèce]

Source :

RBID : pubmed:32565914

Abstract

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide, with a vast majority of confirmed cases presenting with respiratory symptoms. Potential neurological manifestations and their pathophysiological mechanisms have not been thoroughly established. In this narrative review, we sought to present the neurological manifestations associated with coronavirus disease 2019 (COVID-19). Case reports, case series, editorials, reviews, case-control and cohort studies were evaluated, and relevant information was abstracted. Various reports of neurological manifestations of previous coronavirus epidemics provide a roadmap regarding potential neurological complications of COVID-19, due to many shared characteristics between these viruses and SARS-CoV-2. Studies from the current pandemic are accumulating and report COVID-19 patients presenting with dizziness, headache, myalgias, hypogeusia and hyposmia, but also with more serious manifestations including polyneuropathy, myositis, cerebrovascular diseases, encephalitis and encephalopathy. However, discrimination between causal relationship and incidental comorbidity is often difficult. Severe COVID-19 shares common risk factors with cerebrovascular diseases, and it is currently unclear whether the infection per se represents an independent stroke risk factor. Regardless of any direct or indirect neurological manifestations, the COVID-19 pandemic has a huge impact on the management of neurological patients, whether infected or not. In particular, the majority of stroke services worldwide have been negatively influenced in terms of care delivery and fear to access healthcare services. The effect on healthcare quality in the field of other neurological diseases is additionally evaluated.

DOI: 10.1177/1756286420932036
PubMed: 32565914
PubMed Central: PMC7284455


Affiliations:


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<name sortKey="Palaiodimou, Lina" sort="Palaiodimou, Lina" uniqKey="Palaiodimou L" first="Lina" last="Palaiodimou">Lina Palaiodimou</name>
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<nlm:affiliation>Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.</nlm:affiliation>
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<name sortKey="Sharma, Vijay K" sort="Sharma, Vijay K" uniqKey="Sharma V" first="Vijay K" last="Sharma">Vijay K. Sharma</name>
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<nlm:affiliation>Department of Medicine, Division of Neurology, National University Hospital, Singapore.</nlm:affiliation>
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<name sortKey="Chan, Amanda C" sort="Chan, Amanda C" uniqKey="Chan A" first="Amanda C" last="Chan">Amanda C. Chan</name>
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<nlm:affiliation>Department of Medicine, Division of Neurology, National University Hospital, Singapore.</nlm:affiliation>
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<name sortKey="Zand, Ramin" sort="Zand, Ramin" uniqKey="Zand R" first="Ramin" last="Zand">Ramin Zand</name>
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<nlm:affiliation>Department of Neurology, Neuroscience Institute, Geisinger Health System, Danville, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Neuroscience Institute, Geisinger Health System, Danville, PA</wicri:regionArea>
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<name sortKey="Sarraj, Amrou" sort="Sarraj, Amrou" uniqKey="Sarraj A" first="Amrou" last="Sarraj">Amrou Sarraj</name>
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<nlm:affiliation>Department of Neurology, The University of Texas at Houston, Houston, TX, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, The University of Texas at Houston, Houston, TX</wicri:regionArea>
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<name sortKey="Schellinger, Peter D" sort="Schellinger, Peter D" uniqKey="Schellinger P" first="Peter D" last="Schellinger">Peter D. Schellinger</name>
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<name sortKey="Alexandrov, Andrei V" sort="Alexandrov, Andrei V" uniqKey="Alexandrov A" first="Andrei V" last="Alexandrov">Andrei V. Alexandrov</name>
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<nlm:affiliation>Department of Neurology, The University of Tennessee Health Science Center, Memphis, TN, USA.</nlm:affiliation>
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<name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name>
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<div type="abstract" xml:lang="en">The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide, with a vast majority of confirmed cases presenting with respiratory symptoms. Potential neurological manifestations and their pathophysiological mechanisms have not been thoroughly established. In this narrative review, we sought to present the neurological manifestations associated with coronavirus disease 2019 (COVID-19). Case reports, case series, editorials, reviews, case-control and cohort studies were evaluated, and relevant information was abstracted. Various reports of neurological manifestations of previous coronavirus epidemics provide a roadmap regarding potential neurological complications of COVID-19, due to many shared characteristics between these viruses and SARS-CoV-2. Studies from the current pandemic are accumulating and report COVID-19 patients presenting with dizziness, headache, myalgias, hypogeusia and hyposmia, but also with more serious manifestations including polyneuropathy, myositis, cerebrovascular diseases, encephalitis and encephalopathy. However, discrimination between causal relationship and incidental comorbidity is often difficult. Severe COVID-19 shares common risk factors with cerebrovascular diseases, and it is currently unclear whether the infection
<i>per se</i>
represents an independent stroke risk factor. Regardless of any direct or indirect neurological manifestations, the COVID-19 pandemic has a huge impact on the management of neurological patients, whether infected or not. In particular, the majority of stroke services worldwide have been negatively influenced in terms of care delivery and fear to access healthcare services. The effect on healthcare quality in the field of other neurological diseases is additionally evaluated.</div>
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<Title>Therapeutic advances in neurological disorders</Title>
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<AbstractText>The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide, with a vast majority of confirmed cases presenting with respiratory symptoms. Potential neurological manifestations and their pathophysiological mechanisms have not been thoroughly established. In this narrative review, we sought to present the neurological manifestations associated with coronavirus disease 2019 (COVID-19). Case reports, case series, editorials, reviews, case-control and cohort studies were evaluated, and relevant information was abstracted. Various reports of neurological manifestations of previous coronavirus epidemics provide a roadmap regarding potential neurological complications of COVID-19, due to many shared characteristics between these viruses and SARS-CoV-2. Studies from the current pandemic are accumulating and report COVID-19 patients presenting with dizziness, headache, myalgias, hypogeusia and hyposmia, but also with more serious manifestations including polyneuropathy, myositis, cerebrovascular diseases, encephalitis and encephalopathy. However, discrimination between causal relationship and incidental comorbidity is often difficult. Severe COVID-19 shares common risk factors with cerebrovascular diseases, and it is currently unclear whether the infection
<i>per se</i>
represents an independent stroke risk factor. Regardless of any direct or indirect neurological manifestations, the COVID-19 pandemic has a huge impact on the management of neurological patients, whether infected or not. In particular, the majority of stroke services worldwide have been negatively influenced in terms of care delivery and fear to access healthcare services. The effect on healthcare quality in the field of other neurological diseases is additionally evaluated.</AbstractText>
<CopyrightInformation>© The Author(s), 2020.</CopyrightInformation>
</Abstract>
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<Author ValidYN="Y">
<LastName>Tsivgoulis</LastName>
<ForeName>Georgios</ForeName>
<Initials>G</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0002-0640-3797</Identifier>
<AffiliationInfo>
<Affiliation>Second Department of Neurology, National & Kapodistrian University of Athens, School of Medicine, Rimini 1, Chaidari, Athens 12462, Greece.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Palaiodimou</LastName>
<ForeName>Lina</ForeName>
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<AffiliationInfo>
<Affiliation>Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.</Affiliation>
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<LastName>Katsanos</LastName>
<ForeName>Aristeidis H</ForeName>
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<Affiliation>Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.</Affiliation>
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<LastName>Caso</LastName>
<ForeName>Valeria</ForeName>
<Initials>V</Initials>
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<Affiliation>Stroke Unit, University of Perugia - Santa Maria della Misericordia Hospital, Perugia, Italy.</Affiliation>
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<ForeName>Martin</ForeName>
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<Affiliation>Department of Neurology, University of Essen, Essen, Germany.</Affiliation>
</AffiliationInfo>
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<ForeName>Carlos</ForeName>
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<Affiliation>Department of Neurology, Stroke Unit, Hospital Universitari Vall d'Hebrón, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Cordonnier</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
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<Affiliation>Inserm, CHU Lille, U1172 - LilNCog - Lille Neuroscience & Cognition, Univ. Lille, Lille, France.</Affiliation>
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<LastName>Fischer</LastName>
<ForeName>Urs</ForeName>
<Initials>U</Initials>
<AffiliationInfo>
<Affiliation>Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.</Affiliation>
</AffiliationInfo>
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<LastName>Kelly</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>HRB Stroke Clinical Trials Network Ireland and Stroke Service/Department of Neurology, Mater University Hospital/University College, Dublin, Ireland.</Affiliation>
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<LastName>Sharma</LastName>
<ForeName>Vijay K</ForeName>
<Initials>VK</Initials>
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<Affiliation>Department of Medicine, Division of Neurology, National University Hospital, Singapore.</Affiliation>
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<LastName>Chan</LastName>
<ForeName>Amanda C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo>
<Affiliation>Department of Medicine, Division of Neurology, National University Hospital, Singapore.</Affiliation>
</AffiliationInfo>
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<LastName>Zand</LastName>
<ForeName>Ramin</ForeName>
<Initials>R</Initials>
<AffiliationInfo>
<Affiliation>Department of Neurology, Neuroscience Institute, Geisinger Health System, Danville, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
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<LastName>Sarraj</LastName>
<ForeName>Amrou</ForeName>
<Initials>A</Initials>
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<Affiliation>Department of Neurology, The University of Texas at Houston, Houston, TX, USA.</Affiliation>
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<ForeName>Peter D</ForeName>
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<Affiliation>Department of Neurology and Neurogeriatry, Johannes Wesling Medical Center Minden, University Clinic RUB, Minden, Germany.</Affiliation>
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<LastName>Voumvourakis</LastName>
<ForeName>Konstantinos I</ForeName>
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<AffiliationInfo>
<Affiliation>Second Department of Neurology, National and Kapodistrian University of Athens, School of Medicine, "Attikon" University Hospital, Athens, Greece.</Affiliation>
</AffiliationInfo>
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<LastName>Grigoriadis</LastName>
<ForeName>Nikolaos</ForeName>
<Initials>N</Initials>
<AffiliationInfo>
<Affiliation>Second Department of Neurology, "AHEPA" University Hospital, Aristotelion University of Thessaloniki, Thessaloniki, Macedonia, Greece.</Affiliation>
</AffiliationInfo>
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<LastName>Alexandrov</LastName>
<ForeName>Andrei V</ForeName>
<Initials>AV</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-8871-1023</Identifier>
<AffiliationInfo>
<Affiliation>Department of Neurology, The University of Tennessee Health Science Center, Memphis, TN, USA.</Affiliation>
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</Author>
<Author ValidYN="Y">
<LastName>Tsiodras</LastName>
<ForeName>Sotirios</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>4th Department of Internal Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.</Affiliation>
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<Month>06</Month>
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</country>
<region>
<li>Attique (région)</li>
<li>Canton de Berne</li>
<li>Catalogne</li>
<li>Hauts-de-France</li>
<li>Nord-Pas-de-Calais</li>
<li>Pennsylvanie</li>
<li>Tennessee</li>
<li>Texas</li>
</region>
<settlement>
<li>Athènes</li>
<li>Barcelone</li>
<li>Berne</li>
<li>Lille</li>
</settlement>
</list>
<tree>
<country name="Grèce">
<region name="Attique (région)">
<name sortKey="Tsivgoulis, Georgios" sort="Tsivgoulis, Georgios" uniqKey="Tsivgoulis G" first="Georgios" last="Tsivgoulis">Georgios Tsivgoulis</name>
</region>
<name sortKey="Grigoriadis, Nikolaos" sort="Grigoriadis, Nikolaos" uniqKey="Grigoriadis N" first="Nikolaos" last="Grigoriadis">Nikolaos Grigoriadis</name>
<name sortKey="Katsanos, Aristeidis H" sort="Katsanos, Aristeidis H" uniqKey="Katsanos A" first="Aristeidis H" last="Katsanos">Aristeidis H. Katsanos</name>
<name sortKey="Palaiodimou, Lina" sort="Palaiodimou, Lina" uniqKey="Palaiodimou L" first="Lina" last="Palaiodimou">Lina Palaiodimou</name>
<name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name>
<name sortKey="Voumvourakis, Konstantinos I" sort="Voumvourakis, Konstantinos I" uniqKey="Voumvourakis K" first="Konstantinos I" last="Voumvourakis">Konstantinos I. Voumvourakis</name>
</country>
<country name="Italie">
<noRegion>
<name sortKey="Caso, Valeria" sort="Caso, Valeria" uniqKey="Caso V" first="Valeria" last="Caso">Valeria Caso</name>
</noRegion>
</country>
<country name="Allemagne">
<noRegion>
<name sortKey="Kohrmann, Martin" sort="Kohrmann, Martin" uniqKey="Kohrmann M" first="Martin" last="Köhrmann">Martin Köhrmann</name>
</noRegion>
<name sortKey="Schellinger, Peter D" sort="Schellinger, Peter D" uniqKey="Schellinger P" first="Peter D" last="Schellinger">Peter D. Schellinger</name>
</country>
<country name="Espagne">
<region name="Catalogne">
<name sortKey="Molina, Carlos" sort="Molina, Carlos" uniqKey="Molina C" first="Carlos" last="Molina">Carlos Molina</name>
</region>
</country>
<country name="France">
<region name="Hauts-de-France">
<name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name>
</region>
</country>
<country name="Suisse">
<region name="Canton de Berne">
<name sortKey="Fischer, Urs" sort="Fischer, Urs" uniqKey="Fischer U" first="Urs" last="Fischer">Urs Fischer</name>
</region>
</country>
<country name="Irlande (pays)">
<noRegion>
<name sortKey="Kelly, Peter" sort="Kelly, Peter" uniqKey="Kelly P" first="Peter" last="Kelly">Peter Kelly</name>
</noRegion>
</country>
<country name="Singapour">
<noRegion>
<name sortKey="Sharma, Vijay K" sort="Sharma, Vijay K" uniqKey="Sharma V" first="Vijay K" last="Sharma">Vijay K. Sharma</name>
</noRegion>
<name sortKey="Chan, Amanda C" sort="Chan, Amanda C" uniqKey="Chan A" first="Amanda C" last="Chan">Amanda C. Chan</name>
</country>
<country name="États-Unis">
<region name="Pennsylvanie">
<name sortKey="Zand, Ramin" sort="Zand, Ramin" uniqKey="Zand R" first="Ramin" last="Zand">Ramin Zand</name>
</region>
<name sortKey="Alexandrov, Andrei V" sort="Alexandrov, Andrei V" uniqKey="Alexandrov A" first="Andrei V" last="Alexandrov">Andrei V. Alexandrov</name>
<name sortKey="Sarraj, Amrou" sort="Sarraj, Amrou" uniqKey="Sarraj A" first="Amrou" last="Sarraj">Amrou Sarraj</name>
</country>
</tree>
</affiliations>
</record>

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